Develop new blood and urine tests to help detect cancer early

توسعه آزمایش خون و ادرار جدیدی که به تشخیص زودهنگام سرطان کمک می‌کند

British scientists have achieved promising preliminary results for screening tests for faster and easier diagnosis of cancer, which could detect micro-DNA mutations in blood and urine tests.

Diagnosis of cancer in the early stages of the disease is one of the most important issues for experts. Blood and urine are usually tested to diagnose cancer to look for biomarkers that indicate different types of cancer.

Technology introduced Known by this research team as cell-free DNA, or cfDNA, which is small pieces of mutated DNA that enter the bloodstream after cell death. In the case of tumor cell death, these mutations may be similar to the mutations seen in the primary tumor. As a result, blood and urine tests can be used as a tool for cancer screening.

This diagnostic test looks for genetic mutations to diagnose bladder cancer, prostate cancer and three diagnostic proteins for pancreatic cancer. Blood and urine tests may also include other biomarkers that can detect lung cancer through urine.

In late June, Japanese experts published the preliminary results of their research to diagnose a brain tumor through a simple urine test. British scientists have now come up with similar results to diagnose cancer through urine tests.

The Cambridge researchers took the first steps and the experimental phase to investigate this strategy, and examined the condition of eight patients suspected of having a brain tumor based on MRI results, and examined their blood, urine, and cerebrospinal fluid samples. To test for mutations and detect tumor-related cfDNA from 10 blood samples from 12 cases, 10 urine samples from 16 cases, and seven samples from 8 spinal cord fluid samples showed this promising new approach.

The team also used another genome sequence experiment to analyze cfDNA-induced brain tumors. Of the 35 volunteers in the study, 27 showed non-malignant disorders. Next, the researchers plan to compare the effectiveness of this method with MRI.

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