Documentation of new research presented at the annual meeting American Society of Pharmacology And experimental therapy of therapeutic potential Genetically engineered bacteria In the effective treatment of disease Parkinson خبر میدهد.
researchers Bacteria That can synthesize a fixed amount of the drug in the patient’s intestine. Animal experiments have shown that this method is safe and effective in treating Parkinson’s disease.
Ideas Bacterial Engineering It is not a new approach as medical treatment. For years, scientists have been studying ways to use bacteria to treat diseases. For example, researchers have used bacteria to eat excess ammonia in the human body so that they can be involved in the proliferation of colon cancer cells.
Of course, various experiments must be performed before such an idea can be used in practice. New research by a team of scientists shows a step forward in the field of human probiotics E.coli Nissle 1917 Parkinson’s disease drug called L-DOPA is used for continuous synthesis.
Treatment of the disease with the help of bacteria
L-DOPA is a molecule that acts as a precursor to dopamine and has been used as a treatment for Parkinson’s patients for decades. Doctors have found that after about five years of treatment with L-DOPA, patients often develop side effects called dyskinesia. These side effects are thought to be related to the lack of a continuous source of the drug to the brain.
To address this, new research is examining whether it produces bacteria L-DOPA in the intestine They can lead to the continuous delivery of the drug to the brain or not. One of the researchers in this study says that engineered bacteria that eat a molecule called “tyrosine” actually release L-DOPA.
After several repetitions and improvement of drug-based delivery technology Microbiome Intestines Researchers have developed a healthy probiotic bacterium for the gut that can produce stable levels of L-DOPA so that it can be well adjusted to deliver the required dose to each patient.
A study in mice showed that the engineered bacteria produced a constant concentration of L-DOPA in the blood. Examining and testing animal models of Parkinson’s disease, it was found that this treatment improves motor and cognitive function, which shows.