Aging causes nerve stem cells (NSCs) to lose the ability to multiply and produce new nerves and cause forgetfulness. Researchers have now discovered the mechanism of aging in stem cells, as well as how to reactivate the process of neuronal production in the brain.
Stem cells produce new neurons throughout a person’s life in the brain’s hippocampus they produce. This part of the brain plays a key role in memory processes. With age, in patients with Alzheimer’s disease, the hippocampus’ ability to produce new neurons, followed by memory function, decreases.
Researchers in a new study explain how the formation of new neurons is disrupted with age. Nuclear stem cell protein structures ensure the irregular distribution of harmful accumulated proteins in two daughter cells when they divide.
This phenomenon plays an important role in maintaining the ability of cells to proliferate over time to produce new neurons. But with age, the amount of nucleic proteins decreases and the balance in the distribution of harmful proteins between the two daughter cells is lost. Research has shown that this phenomenon reduces the number of new neurons in the brains of older mice.
An important element in this process is a nuclear protein called lamin B1, the level of which decreases with age. As the researchers increased the levels of this protein in older mice, stem cell division improved and the number of new neurons increased.
“As we get older, the body’s stem cells gradually lose the ability to reproduce,” says Khadeesh bin Imtiaz, the lead author of the article. “We were able to identify the mechanism involved in this process using genetic engineering and advanced microscopic technology.”
The findings of this study are an important step in better understanding age-related changes in stem cell behavior.
“We now know we can reactivate aging stem cells in the brain,” said Sebastian Jessberger, a professor at the Institute for Brain Research at the University of Zurich. “We hope that the results of this study will one day help increase the production of new neurons in the brain (neurogenesis) in the elderly and those suffering from degenerative diseases such as Alzheimer’s.”
The results of this research in the journal Cell Stem Cell It has been published.