Researchers have recently discovered that increasing the level of certain proteins in the body’s brown fat can help prevent diabetes in people at risk for type 2 diabetes by altering the behavior of white fat cells.
Researchers at the University of Texas Medical Center in a study on the properties of a protein called “PLIP5” They focused Which covers fat droplets inside the cell, especially brown fats. The researchers in this study looked at mice that had genetically engineered levels of perilipine 5 in their brown adipose tissue.
White fat is a tissue that stores excess energy in the body. On the other hand, brown fat is a type of fat that is burned to keep the body warm. A high percentage of type 2 diabetes is caused by obesity and related diseases such as high blood sugar, insulin resistance and fatty liver. However, the mice engineered in this experiment did not show any of these symptoms compared to mice with normal PLIN5 levels.
Researchers at the University of Texas focused on the effects behind the study. They found that mitochondrial changes in brown adipose tissue caused more fat to burn at room temperature, as if the mice were in a colder room. In addition, the researchers found that white fat cells in the mice became smaller and showed fewer signs of inflammation.
«پری ای. “By using this natural system, we may be able to metabolize adipose tissue healthier and even prevent or treat obesity-induced diabetes,” said Bickel, the study’s lead author. The findings of this study help us better understand how type 2 diabetes and similar diseases are caused by obesity, and provide potential treatments.
However, more needs to be done to transfer this method from animals to humans and to increase our understanding of how brown fats affect white fats. Scientists say it is possible that brown fat transmits some kind of molecular agent to white fat through the bloodstream. Researchers are now trying to find this unknown factor and hope to turn this method into a practical treatment.