Scientists report possible effects of chronic stress on Alzheimer’s disease

دانشمندان از احتمال تاثیر استرس مزمن روی ابتلا به آلزایمر خبر می‌دهند

Alzheimer’s is one of the diseases that we do not know exactly about and we have not been able to find an effective treatment for it. A new study by scientists suggests that chronic stress may also play a role in the development of the disease.

Scientists In his new research They focus on the hypothalamic-pituitary-adrenal axis (HPA axis), which connects two parts of the brain to the adrenal gland. The HPA axis controls a variety of the body’s biological processes and helps us manage stress.

In previous studies, researchers have looked at how chronic stress is associated with Alzheimer’s, and believe that proper management of stress early in life can be one way to reduce the risk of neurological disease. “Growth Molecular Genetics at Curtin University in Australia,” says David Grout.

“What we do know is that chronic stress affects many of the body’s biological pathways. “There is an interrelationship between dealing with chronic stress and being affected by communication pathways related to this stress.”

Part of the HPA’s job is to regulate the secretion of the steroid cortisol, and the more stress, the more cortisol is released. HPA dysfunction and elevated cortisol levels are often seen in Alzheimer’s cases. However, scientists have not yet discovered the real reason for this and what genetic or environmental factors may be involved.

“The study goes on to say:

“Genetic changes in these pathways can also affect how the brain’s immune system works, leading to an inefficient response.” “It also leads to chronic disruption of the normal functioning of the brain and increases the risk of further neurological disease and eventually dementia.”

To be precise, scientists’ hypothesis is that chronic stress can trigger a glucocorticoid response that causes more inflammation of the microglia (brain immune cells), which in turn increases the risk of neurodegenerative diseases such as Alzheimer’s.

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